Monday, December 19, 2011

Ratings threats, North Korea pressure stocks (Reuters)

LONDON (Reuters) ? European stocks and the euro were under pressure on Monday in the wake of a fresh rating agency warning on the euro zone debt crisis, while news of the death of North Korean leader Kim Jong-il sparked fears of regional instability in Asia.

MSCI's world equity index (.MIWD00000PUS) was down around 0.5 percent, while the key FTSE Eurofirst 300 (.FTEU3) opened 0.6 percent lower with other major regional indexes also down. In Asia, South Korea's benchmark index hit a three-week closing low, down 3.4 percent, having fallen as much as 5 percent earlier. (.KS11)

The euro was about 0.1 percent lower at $1.3022, not far from an 11-month low of $1.2944 hit last week, on fears that ratings downgrades for several European countries could derail progress towards resolving the euro zone's debt crisis.

In Asia investors sought the dollar as a safe haven when news of the North Korean leader's death broke, but by 0815 GMT the U.S. dollar index, which tracks the greenback against a basket of currencies, had given up its gains and was flat around 80.25.

"It is hard to predict how things in North Korea will develop from here this time. The news comes at a time when financial markets had already been in fragile shape," said Bae Sung-young, a market analyst at Hyundai Securities.

That fragility was highlighted on Friday when Fitch Ratings warned it may downgrade France and six other euro zone countries, saying a comprehensive solution to the region's debt crisis was "technically and politically beyond reach."

German government bonds were steady early on Monday, supported by some safe-haven buying linked to the death of the North Korean leader and the ratings agency warnings.

While credit downgrades are anticipated, trade is expected to thin out ahead of the Christmas holidays.

Markets are expected to monitor the outcome of a euro zone finance ministers' teleconference from 1430 GMT on Monday.

Commodities, already under pressure due to Europe's sovereign debt crisis, also fell on the North Korean news, with Brent crude off 0.6 percent at about $102.75 a barrel. Gold, usually regarded as a safe-haven asset in times of uncertainty, recovered from losses seen in Asia was steady at $1,591.59 an ounce.

(Editing by Hugh Lawson)

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20111219/bs_nm/us_markets_global

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Sunday, December 18, 2011

Chinese Internet video firms tussle over copyright (Reuters)

SHANGHAI (Reuters) ? Chinese online video companies Tudou Holdings and Youku.com said they will sue each other for alleged copyright infringements of their videos.

Tudou said late on Monday that it would take legal action against Youku, China's top online video site, for allegedly reposting episodes of a popular variety program on Youku's platform.

Cti TV, the legal copyright holder of "Kangxi is Coming," signed an exclusive agreement with Tudou in November to distribute the episodes of the program on its platform, Tudou said in an emailed statement.

Tudou and Cti TV allege that the episodes were then copied by Youku and uploaded onto Youku's platform.

Youku subsequently countered on Friday that it would take legal action against Tudou, accusing Tudou of allegedly pirating more than 60 television serials from Youku.

Youku said in a statement that legal mediation between the two sides had failed.

The battle for content in China's online video space has heated up this year with costs for programs rising significantly as online video players scramble for eyeballs to lure advertisers.

Advertising revenue in the domestic online video market, which was virtually non-existent five years ago, is now estimated to be worth 1 billion yuan ($156.90 million). This is expected to grow at a double-digit rate.

Many online video players have also signed deals with Hollywood studios to boost viewership.

Shares of Tudou closed 2.51 percent lower on the Nasdaq on Thursday, while Youku fell 3.75 percent on the New York Stock Exchange.

($1 = 6.3735 Chinese yuan)

(Reporting by Melanie Lee; Editing by Jacqueline Wong and Matt Driskill)

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/nm/20111216/wr_nm/us_tudou_youku

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The individual mandate: Health-care's inherent controversy (The Week)

New York ? President Obama's health-care bill requires that every American have health insurance. Is that constitutional?

Who first proposed making health insurance compulsory?
The Heritage Foundation, a conservative think tank. In the late 1980s, when Democrats were pushing to require employers to provide health insurance, the foundation started thinking about ways to achieve universal coverage without placing a heavy burden on business. Its experts soon encountered the "free rider" problem: In a system where insurers are barred from refusing applicants with pre-existing conditions, many people ? especially the young and healthy ? would only buy a policy when illness struck. But if only sick people bought coverage, insurers would pay out more in doctors' bills than they received in premiums, and quickly go bust. To overcome this death spiral, the Heritage Foundation suggested that every American be required to buy health insurance, a requirement known as the individual mandate.

Which politicians took up that idea?
Many Republicans did in the early 1990s, after President Clinton introduced a plan that would have forced companies to cover employees. "I am for people, individuals ? exactly like automobile insurance ? having health insurance and being required to have health insurance," said Newt Gingrich, then House minority whip, in 1993. When the Clinton plan collapsed in 1994, talk of the individual mandate died with it. But a decade later, Mitt Romney, then the governor of Massachusetts, resurrected the concept for his state health-care plan, which requires residents to buy health insurance or pay up to $1,212 in annual penalties. "It's a Republican way of reforming the market," Romney said when the law debuted, in 2006. "[To have] people show up [at a hospital] when they get sick, and expect someone else to pay, that's a Democratic approach."

SEE MORE: Should the Supreme Court's 'ObamaCare' arguments be televised?

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So why did Obama adopt a Republican proposal?
At first, he didn't want to. During his 2008 campaign for the Democratic nomination, Obama ran a TV ad criticizing rival candidate Hillary Clinton's support for a mandate, saying she would force everyone "to buy insurance, even if you can't afford it." But after President Obama and the Democratic Congress began to construct his health-care plan, advisers warned that free riders would undermine the objectives of extending insurance coverage to anyone who wanted it. For health reform to work, young, healthy people had to be pushed into the pool, to spread cost and risk. So the president allowed his 2010 Affordable Care Act to incorporate a provision that, by 2014, all Americans must have health coverage or face a tax penalty. Conservatives decried that directive as a gross infringement of individual liberty, and their anger helped fuel the rise of the Tea Party. Twenty-six states and the National Federation of Independent Business are now challenging the mandate's constitutionality at the Supreme Court, which will make a final judgment by June.

How has Obama responded?
His administration argues that the mandate is authorized by the Constitution's commerce clause, which allows the federal government to regulate interstate economic activity. Several conservative judges agree. In a November appeals court decision that upheld the mandate, Judge Laurence Silberman, a Reagan appointee, declared that Congress must "be free to forge national solutions to national problems." And this summer, Judge Jeffrey Sutton ? a George W. Bush appointee to the 6th Circuit Court of Appeals ? concluded that the individual mandate is a legally sound way to prevent taxpayers and hospitals from having to pick up the cost of treating the uninsured. "Not every intrusive law is an unconstitutionally intrusive law," he wrote.

SEE MORE: The Supreme Court takes on 'ObamaCare': Will it hurt the president?

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Haven't other judges disagreed?
Yes. In August, the 11th Circuit Court of Appeals declared that it could find no precedent for ordering Americans to buy health insurance. "Even in the face of a Great Depression, a World War, a Cold War, recessions, oil shocks, inflation, and unemployment," the majority wrote, "Congress never sought to require the purchase of wheat or war bonds, force a higher savings rate or greater consumption of American goods." Other federal judges and critics of "Obamacare" warn that the mandate sets a dangerous precedent that the government could use to make citizens purchase whatever it deems good for them ? or for the economy. "Congress could require every American to buy a new Chevy Impala every year," said a 2009 Heritage Foundation report.

What happens if the individual mandate is voided?
It depends. If the Supreme Court decides that the Affordable Care Act can't function without the individual mandate, it could strike down the entire law. But it might declare the mandate "severable," and remove that particular part of the law, while letting the rest of it limp along, with far fewer uninsured people covered and less ability to rein in costs. Some experts have proposed that instead of the uninsured being required to buy insurance, they could be "nudged" into the health-care system by giving them a window of time during which they could buy insurance relatively inexpensively; once that window closed, the cost would rise sharply. The problem with any alternative to the individual mandate, said Paul Ginsburg, president of the Center for Studying Health System Change, is that it would have to be approved by the bitterly divided Congress. "You can't expect that in these times," he said. "People don't work on these compromises too readily anymore."

SEE MORE: A conservative judge's 'compelling' defense of 'ObamaCare'

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How the Supreme Court could punt
Next year's Supreme Court hearing has been billed as judgment day for Obama's Affordable Care Act. But it might end with no judgment at all. Before the justices rule on the individual mandate's constitutionality, they will first have to decide whether the 1867 Anti-Injunction Act bars the claimants' challenge. That law prevents citizens from challenging the legality of a tax before it goes into effect. If the court finds that the penalty for defying the Affordable Care Act's mandate is a tax, they could push a legal challenge back to 2015, when the first fines will be levied. And that, said Simon Lazarus, an expert at the National Senior Citizens Law Center, might "be a good solution for a court that doesn't really care to be Public Issue No. 1 in an election year."

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Saturday, December 17, 2011

Dems Cave on Millionaire Surtax with No Deal in Sight (The Atlantic Wire)

It was a key Democratic demand but party leaders abandoned a surtax on millionaires to finance a payroll tax holiday Wednesday night in return for, well, nothing, as of yet.

Related: Government Shutdown Looms as Payroll Tax Talks Stall

Yesterday, top Senate Democrats and President Obama met to consider dropping a 1.9 percent surtax on people earning more than $1 million per year and ultimately decided to abandon it. In response, Michael Steel, spokesman for House speaker John Boehner, told the AP "I don't think it's much of a concession. It never had any chance of passing the Senate, let alone the House."

Related: The Remaining Sticking Points on a Payroll Tax Deal

Some analysts last week predicted that a concession to drop the surtax could be exchanged for the Republicans dropping a provision to fast-track the Keystone XL oil sands pipeline but Republicans gave no sign such a deal was in the works.?

Related: Obama Raises the Stakes on the Payroll Tax Impasse

Instead,?Roll Call?reports that Republicans are planning a parliamentary tactic to force Senate Democrats to vote on an omnibus spending bill preventing Republicans from compromising on the payroll tax package. Republicans would essentially bring the spending bill to the floor on Friday, daring Senate Democrats to oppose it with most parts of the government set to shutdown on Saturday. It's a little confusing but as?Roll Call?explains, it essentially amounts to this: "The move would be an attempt to undercut Democrats' strategy of refusing to formally sign off on the spending bill until Republicans and Democrats can reach agreement on an extension of President Barack Obama's payroll tax holiday."

Related: The Compromise Boehner and Reid Will Have to Make

The president would like to resolve the issue by Congress passing a short-term spending bill and working through Christmas break, which begins Friday, as Politico's Manu Raju and Jake Sherman report. "The White House put out a strongly worded statement Wednesday night calling on Congress to put off a mammoth $1 trillion government funding bill that Republicans had demanded as a condition for passing the payroll tax cut.?Instead, the White House wants a short-term spending bill, an idea many Republicans have scoffed at."?

Related: Government Funding Bill Fails Over Cuts to Pay for Disaster Relief

Both parties have said it's important to pass a payroll tax break and it appears the American people agree. According to a new Associated Press-GfK survey, 58 percent of respondents say Congress should pass the tax holiday measure. "Nearly 6 in 10 respondents say they want Congress to pass the extension, according to the poll. Letting the payroll tax break expire would cost a family making $50,000 about $1,000," reports the AP.

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Silver Lake, Microsoft working on new Yahoo stake offer: source (Reuters)

(Reuters) ? A consortium of private equity group Silver Lake, software giant Microsoft Corp and venture capital firm Andreessen Horowitz are reworking their bid for a minority stake in Internet company Yahoo Inc, a source familiar with the matter said on Friday.

Silver Lake's consortium is working on a new offer for a stake of 10 to 15 percent in Yahoo after the company asked for improved terms, the source said.

The new offer would be predicated on Yahoo finding a new, world-class chief executive that the consortium would support, the source added. Yahoo's board fired CEO Carol Bartz in September and has yet to hire a permanent replacement.

The Wall Street Journal reported earlier on Friday, citing people familiar with the matter, that private equity firms seeking to acquire just under 20 percent of Yahoo were working on new offers for a smaller stake at a higher per-share valuation.

TPG Capital, which sources previously told Reuters had also bid for a minority stake, did not respond to a request for comment. Representatives of Silver Lake and Microsoft declined to comment while an Andreessen Horowitz spokeswoman could not immediately be reached for comment.

"As previously announced, the board is evaluating various alternatives as part of its comprehensive strategic review process, all of which are designed to enhance shareholder value and promote growth and innovation at Yahoo," a Yahoo spokesman said.

"The board's process is open to all alternatives and has not restricted the range of various options or proposals in any way," he added.

The first offer by Silver Lake's consortium valued Yahoo at $16.6 per share, about $1 per share less than what TPG proposed, people familiar the matter had previously told Reuters. Yahoo shares closed down 1.3 percent at $14.96 on Friday.

Yahoo has several available options. Chinese e-commerce giant Alibaba, in which Yahoo has a 40 percent stake, is preparing a $4 billion bank loan to buy back that stake, Thomson Reuters publication Basis Point reported on Thursday, citing sources.

But Alibaba could choose to partner with buyout groups Blackstone Group LP and Bain Capital and Japan's Softbank Corp for a full-out bid for Yahoo, sources familiar with the matter have previously told Reuters.

Private equity firm Thomas H. Lee Partners is interested in buying the U.S. operations of Yahoo, people familiar with the matter have also told Reuters previously.

Yahoo's difficulty in competing with Internet heavyweights such as Google and Facebook have forced it to explore proposals to revamp its business. Yahoo has a market capitalization of $18.5 billion.

(Reporting By Greg Roumeliotis in New York, Alexei Oreskovic in San Fransisco and Bill Rigby in Seattle; Editing by Gary Hill)

Source: http://us.rd.yahoo.com/dailynews/rss/software/*http%3A//news.yahoo.com/s/nm/20111217/bs_nm/us_yahoo

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Friday, December 16, 2011

Human proteins that may fuel HIV/AIDS transmission identified

ScienceDaily (Dec. 14, 2011) ? Scientists at the Gladstone Institutes have discovered new protein fragments in semen that enhance the ability of HIV, the virus that causes AIDS, to infect new cells -- a discovery that one day could help curb the global spread of this deadly pathogen.

HIV/AIDS has killed more than 25 million people around the world since first being identified some 30 years ago. In the United States alone, more than one million people live with HIV/AIDS at an annual cost of $34 billion.

Previously, scientists in Germany discovered that HIV transmission is linked to the presence of an amyloid fibril in semen. This fibril -- a small, positively charged structure derived from a larger protein -- promotes HIV infection by helping the virus find and attach to its target: CD4 T white blood cells. In the December 15 issue of Cell Host & Microbe, researchers in the laboratory of Warner C. Greene, MD, PhD, who directs virology and immunology research at Gladstone, describe a second type of fibril that also has this ability.

These findings may spur efforts to slow the spread of HIV/AIDS. Prevention has recently focused on microbicides; chemical gels that, when used by women during sexual intercourse, block HIV infection. But while early microbicides had some success -- reducing infection by an average of 39% -- more recent trials have failed and devising a truly potent microbicide remains a top priority.

"Today's microbicides may be failing because, while they do target the virus itself, they don't block the virus from interacting with the natural infection-enhancing components of semen," said Nadia R. Roan, PhD, the paper's first author and a research scientist at Gladstone, an independent and nonprofit biomedical-research organization. "Now that we more fully understand how HIV hijacks these components to promote its own infection, we are one step closer to developing a microbicide that can more effectively stop HIV."

Sexual transmission accounts for the vast majority of HIV infections, and semen is the virus' key mode of transport. Earlier studies by Drs. Roan and Greene revealed the mechanism by which a positively charged fibril in semen -- called SEVI -- attracts HIV like a magnet, binding to the negatively charged HIV and helping to infect CD4 T cells. Here, they set out to investigate whether other components of semen also played a part.

In laboratory experiments on human semen samples, they identified a second set of fibrils -- derived from larger proteins called semenogelins -- that enhance HIV infection just as SEVI does. Removing these and other positively charged components from semen diminished HIV's ability to infect CD4 T white blood cells. Further confirming the role of these fibrils in promoting HIV infection, Drs. Roan and Greene found that semen samples from men who are naturally deficient in semenogelins -- a disorder called ejaculatory-duct obstruction -- also had a limited ability to enhance HIV infection.

"Our experiments suggest that fibrils derived from semenogelins -- the major component of semen -- are integral to enhancing HIV infection in semen," said Dr. Roan. "But we are intrigued by their natural, biological function as well. The fact that these fibrils are found in male reproductive organs could point to an evolutionary role in fostering fertilization -- something we're currently exploring."

"We hope that this research paves the way for the next-generation of microbicides that can both neutralize these fibrils and attack the virus," said Dr. Greene, who is also a professor of medicine, microbiology and immunology at the University of California, San Francisco, with which Gladstone is affiliated. "This type of one-two punch in a microbicide -- what current products lack -- could finally give women real protection against HIV's deadly attack."

Gladstone Research Associate Simon Chu also participated in this research, which was made possible by a research grant that was awarded and administered by the U.S. Army Medical Research and Material Command and the Telemedicine & Advanced Technology Research Center at Fort Detrick, MD, under Contract Number W81XWH-11-1-0562. Additional support came from the Giannini Foundation, the National Institutes of Health and the German Ministry of Science.

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The above story is reprinted from materials provided by Gladstone Institutes.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Nadia?R. Roan, Janis?A. M?ller, Haichuan Liu, Simon Chu, Franziska Arnold, Christina M. St?rzel, Paul Walther, Ming Dong, H.?Ewa Witkowska, Frank Kirchhoff, Jan M?nch, Warner?C. Greene. Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection. Cell Host & Microbe, 2011; 10 (6): 541 DOI: 10.1016/j.chom.2011.10.010

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111214125850.htm

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Chris Paul trade: Can the Clippers become LA's team?

Chris Paul, the coveted free agent point guard, could turn the lowly Clippers into a serious NBA contender. The addition of Chris Paul to the team is attracting other marquee players.

Everybody?s talking basketball in Los Angeles, but for perhaps the first time ever, it?s not about the Lakers.

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That?s because the lowly Clippers, the perennial stepchild of the city?s basketball scene, have locked up a trade for Chris Paul, the most highly coveted free agent point guard of the NBA offseason.

Paul wasn?t a bargain: The Clippers acquired him, along with two second-round draft picks, from the New Orleans Hornets in exchange for guard Eric Gordon, forward Al-Fariq Aminu, and Minnesota?s 2012 unprotected first-round draft pick.

But by most accounts, it was worth it. NBA experts are already predicting that Paul?s addition to the Clippers will catapult the franchise, which has been embarrassingly inept for most of its existence, into a title contender with ticket sales to compete with its local rival.

The change would be welcome: Throughout their 40-year history, the Clippers have been the NBA?s resident joke. The franchise has only had six winning seasons in its entire existence, and only two since moving to Los Angeles from San Diego in 1984. The oldest NBA team never to have appeared in the league finals, the Clippers haven?t made it past the first round of playoffs since 1976, when they were the Buffalo Braves. To make matters worse, they share the Staples Center with the Lakers, a franchise that boasts 16 NBA titles, 16 Hall of Famers, and a fan base littered with A-list celebrities.

But this season, roles may be reversed. Paul, a sixth season player who has established himself as one of the best point guards the league has ever seen, will be joining up with Blake Griffin, the power forward who was a first overall draft pick for the Clippers in 2009. In his first season, Griffin was a human highlight reel, averaging 22.5 points per game, winning the league?s Slam Dunk Contest, and becoming the first man unanimously voted Rookie of the Year in over two decades. Griffin alone made the Clippers worth watching. But Griffin and Paul, along with guard Chauncey Billups, forward Caron Butler, and center DeAndre Jordan, will lay the groundwork for them to become championship contenders. Adding to the intrigue is that the Lakers nearly had Paul: Last week, NBA commissioner David Stern blocked a deal that would have sent him there, saying that the agreement was unfair to the small-market Hornets.

In rounding out their roster, the Clippers have a better chance of making Blake Griffin a permanent Clipper and attracting even more marquee players to the organization. That?s great news for the team, in terms of both basketball and business.? As of this morning, season ticket packages for the Clippers were sold out, and CNBC is reported that the average price for an individual ticket has risen from $268.32 to $303.88 since 7:45 this morning. That?s a $35.56 increase in a matter of hours.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/jekCMT55WhI/Chris-Paul-trade-Can-the-Clippers-become-LA-s-team

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